In 1988, a noteworthy ruling by DEA judge Francis L. Young asserted that “Marijuana, in its natural form, is one of the safest therapeutically active substances known.”

He highlighted the near impossibility of overdosing on cannabis, with the toxic threshold requiring an astonishing 1,500 pounds in just 15 minutes.

Despite this, it’s crucial to recognize that consuming any amount of marijuana isn’t entirely risk-free. Excessive use may lead to various unpleasant and potentially hazardous side effects.

This article delves into the potential consequences of overindulging in marijuana, shedding light on the likely outcomes based on the consumption method.

No overdose doesn’t mean no side effects

A 2002 review published in the Western Journal of Medicine tackled the question: Should Physicians Support the Medical Use of Marijuana?

According to author William S. Eidelman, the answer was affirmative when all else failed. He explored reports suggesting potential therapeutic benefits of cannabis, including a 1999 Institute of Medicine report supporting medical marijuana use.

A Johns Hopkins University study revealed no significant cognitive decline differences among non-users, heavy users, and moderate cannabis users, emphasizing the significant benefits outweighing the risks.

Nearly two decades later, subsequent studies echo similar conclusions. Nevertheless, it is essential to acknowledge the potential side effects of excessive cannabis consumption.

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Has marijuana ever resulted in fatality?

Distinguishing between whether marijuana has caused death and whether it has led to an overdose is crucial. Considering the substantial THC quantity required for a technical ‘overdose,’ the answer to the latter question is ‘no.’ While a few reports are suggesting the contrary, the details are often unclear.

However, asserting that cannabis has never resulted in any deaths is inaccurate. The tragic case of Levy Thamba illustrates the severe consequences of excessive marijuana use.

Consuming a cannabis cookie with 65mg of THC (recommended serving: 10mg), Thamba experienced paranoid delusions and hallucinations, ultimately leading to a fatal fall from a hotel balcony.

Excessive cannabis use may result in:

• Impaired coordination and altered perception
• Hallucinations
• Increased heart rate
• A heightened sense of panic, fear, anxiety, or paranoia
• Decreased reaction time
• Time dilation

Driving or operating heavy machinery under the influence of cannabis can lead to tragic outcomes. Understanding cannabis dosage is crucial, as it varies based on the consumption method.

THC, the primary intoxicating cannabinoid in marijuana, offers therapeutic benefits when used responsibly. However, when abused, it can lead to the mentioned side effects. The ensuing guidelines focus on cannabis THC content.

Comprehensive dosage guidelines: Understanding THC impact

In determining THC dosage, it’s crucial to recognize the individualized nature of its effects, as no two individuals are likely to experience identical reactions. Various factors play a pivotal role in influencing your response to the cannabinoid, including:

• Previous cannabis use
• Bodyweight
• Endocannabinoid system (ECS)
• Gastrointestinal factors
• Consumption method
• General health

Approximately 3% of the population exhibits extreme sensitivity to THC, feeling its effects with as little as 1mg. To provide a general overview, we outline potential outcomes associated with different THC amounts.

Up to 2.5mg:

Mild pain relief and improved focus may be experienced at this dosage. The impact is generally subtle and unlikely to cause significant effects.

6 – 15mg:

At this level, effects such as euphoria and impaired coordination may occur, especially in inexperienced users.

16 – 30mg:

Considered an extremely high dose for novices, even experienced users may feel altered perception. Individuals with a low THC tolerance may encounter negative side effects at this consumption level.

31 – 50mg:

Reserved for very experienced cannabis users, this amount may lead to unpleasant side effects like paranoia, sweating, and increased heart rate.

51+mg:

Deemed a dangerous dosage for novices and those with a low to moderate THC tolerance, this level of consumption may induce hallucinations and terrifying effects.

Levy Thamba’s unfortunate case serves as a stark reminder, as he consumed 65mg of THC, resulting in tragic consequences.

Understanding these dosage guidelines is paramount for ensuring a safe and enjoyable cannabis experience, considering the diverse factors influencing THC sensitivity.

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The significance of consumption method in cannabis use

Understanding the consumption method is paramount, given that certain methods yield higher bioavailability than others. ‘Bioavailability’ refers to the degree and rate at which a substance is absorbed into the bloodstream, where it is utilized as needed.

For instance, if you consume 10mg of THC and your chosen method has a 20% bioavailability rate, only 2mg of THC enters the bloodstream and exerts its effects.

A study published in Pain Research & Management in 2005 suggests that the average bioavailability of THC is around 30%.

Dried cannabis flower

Judging the THC content in a joint or bowl can be challenging, as not many individuals weigh their bud before consumption. The best approach is to determine the THC content of the cannabis strain, allowing you to estimate the content in a gram.

Consider Northern Lights, with an 18% THC content. Calculating, you’d find that a gram contains 1,000mg x 0.18, resulting in 180mg of THC.

Understanding these aspects enhances your ability to gauge and control your cannabis dosage effectively.

Cannabis dosage breakdown: Northern lights example

Let’s break down the dosage when using 0.25 grams of Northern Lights. With a THC content of 18%, the initial calculation yields 180 x 0.25, resulting in 45mg of THC.

However, factoring in the bioavailability of dried cannabis, set at 27% by a Canadian Government study, the adjusted dosage that enters your bloodstream is 45 x 0.27, equating to 12.15mg of THC.

This dosage is anticipated to induce intoxicating effects, yet it should remain manageable for most users. It’s important to note that smoked cannabis can take effect within 10 minutes, according to Canadian researchers, with effects potentially lasting up to six hours.

Vaporized cannabis

Vaporizers, accommodating dried cannabis flowers, specialized vape juices, or high-THC concentrates, offer an alternative consumption method.

When purchasing a specific vape liquid from a licensed retailer, the product should clearly outline its THC content.

For instance, a 1ml cartridge labeled 90% THC provides up to 900mg of THC. With a minimal requirement of 0.01ml, you can achieve 9mg of THC. Vaporized THC bioavailability ranges between 36% and 61%, contingent on the study you reference.

Understanding these nuances in dosage and consumption methods empowers users to make informed decisions, ensuring a more controlled and enjoyable cannabis experience.

Fine-tuning THC dosage: Vape juice and oral consumption insights

Vape Juice Dosage

At the upper limit, consuming 0.01ml of our 90% THC vape juice translates to 9 x 0.61, resulting in 5.49mg of THC absorbed into the bloodstream.

Novices may find this sufficient to feel an effect, while experienced users might opt for 0.05ml, ensuring 27.45mg of THC reaches the bloodstream. Rapid onset, typically within 10-30 minutes, and a potential duration of up to six hours characterize the effects.

Oral Consumption

Orally consumed THC boasts the lowest bioavailability rate. While estimates vary, products like edibles, capsules, or orally administered THC oils likely have a maximum absorption rate of 20%.

Cannabis edibles, a popular choice, come with the highest risk of side effects due to the method’s propensity for excessive THC consumption.

The appeal often lies in their delectable taste, and a significant risk factor is the extended two-hour onset period. Inexperienced users, frustrated by delayed effects, may unknowingly consume more, leading to unintended consequences.

Understanding the intricacies of vape juice dosages and the unique challenges of oral consumption equips users with the knowledge needed to navigate these methods responsibly, enhancing their overall cannabis experience.

THC Syrup (1000 MG THC) – Orange and Mango

Navigating edibles, topicals, and final cannabis dosage considerations

Edibles: A Potency Caution

Dispensaries typically advocate commencing with 10mg of THC when using edibles. Considering a 20% bioavailability rate, only 2mg of THC enters the bloodstream.

However, edibles exert a more potent effect on the body compared to other consumption forms. Users often find the impact stronger, emphasizing the need for cautious initial dosing.

Both capsules and THC oil products, providing THC content information, should also be limited to a maximum of 10mg initially.

Cannabis Topicals: A Unique Challenge

Topicals’ bioavailability rate is less studied, complicating dosage determination. Applied directly to the skin, products like creams or balms are gaining popularity due to their non-intoxicating effects.

While topicals won’t induce a high, it’s prudent to start with a small amount. THC transdermal patches release the cannabinoid into the body, albeit slowly, minimizing the likelihood of intoxication.

Final thoughts on cannabis dosage

While marijuana offers diverse benefits and the impossibility of a fatal cannabis overdose, excessive THC use can lead to a range of side effects, varying in severity with increased dosage.

Refer to the provided guidelines for THC dosing, adopting a ‘low and slow’ approach initially. Overindulgence risks compromising the overall experience, so exercise caution in your cannabis journey.

 

Disclaimer: The information provided on this page is for educational purposes only and should not be considered medical advice. Always consult with a healthcare professional before using any THC product.