Ever shared a joint with a friend only to witness them getting significantly higher than you? Or perhaps found yourself overwhelmed while others at the gathering were seemingly unaffected?

The divergent responses to cannabis among individuals remain a puzzling phenomenon.

Understanding cannabis’s impact on the body and mind

Cannabis comprises numerous active compounds like cannabinoids, terpenes, and flavonoids. Yet, one compound stands out: THC (delta 9 tetrahydrocannabinol), renowned for its role in inducing the high associated with cannabis use.

THC’s intoxicating effects stem from its molecular resemblance to anandamide, a naturally occurring body chemical. Anandamide binds to specific cell receptors, triggering various physical and psychological reactions by influencing neurotransmitters like serotonin and dopamine.

Interacting with serotonin and dopamine, anandamide significantly impacts mood, emotion, and ‘executive function’—encompassing mental activities such as learning, memory, planning, and decision-making.

THC mimics anandamide’s shape, allowing it to bind to the same receptors, albeit with stronger effects. This interaction is the primary cause of the typical marijuana-induced high.

For many, THC’s effects yield euphoria, relaxation, altered sensory perceptions, and time dilation. However, adverse effects like memory lapses, reduced concentration, and drowsiness can occur. Certain individuals may also experience heightened anxiety or paranoia.

Beyond impacting the brain, THC interacts with cells throughout the body, leading to physical side effects such as dry mouth, dry eyes, increased appetite, and potential alterations in heart rate and circulation.

Nevertheless, these effects aren’t universal for all cannabis users. Variations in individual experiences prompt the question: what accounts for these differences?

Why do individuals react differently to cannabis?

Several factors contribute to the varying effects of cannabis on individuals, leading to diverse experiences, even with identical doses. Factors influencing these differences encompass:

The impact of strain composition and consumption method

1. THC Concentration: Varying levels of THC in the chosen strain.
2. Cannabinoids and Terpenes: Presence and proportion of other compounds in the strain.
3. Consumption Method: Diverse methods like smoking, vaping, edibles, etc.
4. Quantity Consumed: The amount of cannabis intake.

Despite these variables, two individuals using the same cannabis at the same time might still encounter dissimilar effects. The primary reason for this divergence lies in:

Role of genetics

Genetics significantly shape how individuals respond to cannabis. Unique genetic compositions render some individuals more adept at handling cannabis than others.

A 2013 study in Neuropsychopharmacology examined 86 cannabis users and 58 non-users, evaluating their executive function through various tests.

Genetic differences were analyzed via blood samples. The study revealed that while daily cannabis use didn’t autonomously impair executive function, genetic disparities played a pivotal role in altering it.

For instance:

• Cannabis users with a COMT val/val genotype exhibited diminished sustained attention compared to non-users with the same genotype.
• Those with a met/met genotype faced fewer challenges in monitoring/shifting tasks than their counterparts.
• Users with a 5-HTTLPR s/s genotype encountered difficulties in decision-making.

Genetics influence cannabis effects by modulating the availability of receptors for THC binding. A 2017 study in Cannabis and Cannabinoid Research highlighted that the rs2023239 gene increased CB1 receptor expression in cells.

Ongoing research delves deeper into how genetics impact cannabis effects, indicating that it stands as a primary determinant in how cannabis affects an individual’s body and mind.

Factors influencing cannabis experience

A person’s prior attitude and expectations significantly influence their cannabis high. Approaching cannabis with a positive mindset often yields a more positive experience, whereas apprehension may heighten anxiety during use.

Environmental factors also play a crucial role; consuming cannabis in a safe and familiar space tends to enhance the overall experience.

Dose discrepancies

Dose disparities represent a notable determinant in how individuals handle weed. Even when sharing a joint, variations in inhalation depth and holding duration affect THC absorption, altering individual doses.

However, it’s cautioned against holding smoke excessively, considering potential respiratory risks.

Tolerance development

Tolerance stands as a substantial reason for the divergent impact of cannabis. Heavy or regular usage prompts the body to adapt, requiring increased amounts for similar effects—a phenomenon known as tolerance.

While a high THC tolerance reduces the likelihood of adverse effects, it may also challenge achieving desired levels of intoxication.

Frequent cannabis use correlates with reduced activity at cannabinoid cell receptors. Consequently, heavy users might struggle to reach the highs experienced by occasional users.

Combatting tolerance involves several strategies, including:

• Strain Rotation: Switching between strains regularly.
• Altering Consumption Method: Changing how cannabis is consumed.
• Strategic Breaks: Taking planned intervals of abstinence, termed ‘tolerance breaks.’ Research suggests that cannabinoid receptor activity increases after a few days of cessation, aiding in resetting one’s ability to get high.

Understanding these factors can significantly influence how individuals perceive and manage their cannabis consumption, ensuring a more tailored and controlled experience.

Influence of concurrent substances

The impact of cannabis on an individual can be influenced by concurrent substance use. Combining cannabis with alcohol, for instance, often intensifies intoxication compared to cannabis use alone.

Additionally, interactions with certain over-the-counter or prescription medications may heighten the effects of either the medication or marijuana, necessitating caution when using cannabis alongside pharmaceuticals.

Tailoring cannabis use

• Medical Use: For medical cannabis users, consulting with a physician helps determine an appropriate dosage, considering potential interactions with other medications.
• Recreational Use: Awareness is crucial for recreational users, as combining marijuana with other substances can significantly alter its effects.

Final thoughts on handling weed differently

Numerous factors contribute to why individuals react diversely to cannabis. Experience, attitudes, expectations, and genetic variations all play pivotal roles.

However, regardless of one’s response to cannabis, there are strategies to enhance the experience:

• Managing Intensity: Start with a low dose and gradually increase for those sensitive to cannabis effects. Opt for less potent strains or high CBD/low THC varieties for a milder experience.
• Tolerance Management: Experienced users grappling with reduced highs can explore different strains or consumption methods. Taking breaks from cannabis consumption remains the most effective strategy to combat tolerance.

Understanding these dynamics empowers individuals to tailor their cannabis use for a more personalized and controlled experience.

Disclaimer: The information provided on this page is for educational purposes only and should not be considered medical advice. Always consult with a healthcare professional before using any THC product.